Publications

At NYU

  1. Ziva Moravec, Yue Zhao, Rhianne Voogd, Danielle R. Cook, Seon Kinrot, Benjamin Capra, Haiyan Yang, Brenda Raud, Jiayu Ou, Jiekun Xuan, Teng Wei, Lili Ren, Dandan Hu, Jun Wang, John B.A.G. Haanen, Ton N. Schumacher, Xi Chen, Ely Porter, Wouter Scheper. Discovery of tumor-reactive T cell receptors by massively parallel library synthesis and screening, Nature Biotech. 2024, in press.
  2. Elliot Philips, Jia Liu, …, Michael Dustin*, Jun Wang*, Xiangpeng Kong*. Transmembrane Domain Driven PD-1 Dimers Mediate T Cell Inhibition, Sci. Immunol. 2024. (*Corresponding author)
  3. John L. Silberstein, Jasper Du, …, Xiangpeng Kong, Jun Wang*, Jennifer Cochran*. Structural basis for LAG-3 dimeric association and inhibition of T cell function, PNAS. 2024. (*Corresponding author)
  4. Jun Wang*, Qiao Lu, Xufeng Chen, and Iannis Aifantis*. Targeting MHC-I inhibitory pathways for cancer immunotherapy., Trends in immunology. 2024. (*Corresponding author)
  5. Tae Kon Kim, Xue Han, Qianni Hu, Esten N Vandsemb, Carly M Fielder, Junshik Hong, Kwang Woon Kim, Emily F Mason, R Skipper Plowman, Jun Wang, …, Steven D Gore, Lieping Chen. PD-1H/VISTA mediates immune evasion in acute myeloid leukemia. J Clin Invest. 2023
  6. Xufeng Chen, Qiao Lu, …, Iannis Aifantis*, Jun Wang*. A membrane-associated inhibitory axis of MHC-I antigen presentation for cancer immune evasion. Cell, 2023. (*Corresponding author)
  7. Melero, Ignacio, Miguel F Sanmamed, Javier Glez-Vaz, Carlos Luri-Rey, Jun Wang, Lieping Chen. “CD137 (4-1BB)-Based Cancer Immunotherapy on Its 25th Anniversary.” Cancer discovery, OF1-OF19. 2022
  8. Fei Shu, Salman R Punekar, Vamsidhar Velcheti, Miguel F. Sanmamed, Jun Wang*, PD-L1 crosslinking as a new strategy of 4-1BB agonism immunotherapy.. Clinical Cancer Research. 2022. (*Corresponding author)
  9. Linghua Zheng, Xue Han, Sheng Yao, Yuwen Zhu, John Klement 2, Shirley Wu 2, Lan Ji, Gefeng Zhu, Xiaoxiao Cheng, Zuzana Tobiasova, Weiwei Yu, Baozhu Huang, Matthew D Vesely, Jun Wang, Jianping Zhang, Edward Quinlan, Lieping Chen, CD8α-PILRα interaction maintains quiescence of naive and memory CD8+ T lymphocytes. Science. 2022.
  10. Runxia Gu, Tianyang Mao, Qiao Lu, Tina Tianjiao Su*, Jun Wang*, Myeloid dysregulation and therapeutic intervention in COVID-19. Semin Immunol. 2021 Nov 9:101524. (*Corresponding author)
  11. Qiao Lu, Jia Liu, Shuai Zhao, Maria Florencia Gomez Castro, Maudry Laurent-Rolle, Jianbo Dong…, Peter Cresswell, Yue Liu, Siyuan Ding*, Qi Xie*, Jun Wang*, ACE2 independent SARS-CoV-2 myeloid cell interaction exacerbates inflammatory responses, Immunity, 2021 May 9: S1074-7613(21)00212-0. (*Corresponding author)
  12. Wei Hu, Yong Zhang, Panyu Fei, Tongtong Zhang, Danmei Yao,..., Jun Wang*, Zhenhai Li*, Jizhong Lou*, Wei Chen*, Mechanical activation of spike determines SARS-CoV-2 viral infection, Cell Research, 2021. (*Corresponding author)
  13. Tianshi Lu, Ze Zhang, James Zhu, Yunguan Wang, Peixin Jiang, Xue Xiao, ..., Jun Wang, Lin Xu, Alexandre Reuben, Tao Wang, Deep learning-based prediction of the T cell receptor-antigen binding specificity, Nature Machine Intelligence, 2021.
  14. Tessa Barrett, Seda Bilaloglu, Maclntosh Cornwell, ..., Jun Wang, Camelia Iancu-Rubin, Hannah M Burgess, Ian Mohr, Kelly Ruggles, Kenneth Stapleford, Judith Hochman, Jeffery Berger. Platelets Contribute to Disease Severity in COVID-19, Journal of Thrombosis and Haemostasis, 2021, Sep 19.
  15. Miguel Sanmamed, Xinxin Nie,..., Jun Wang, Roy Herbst, Kurt Schapler, Lieping Chen, A burn-out CD8+ T-cell subset expands in the tumour microenvironment limiting cancer immunotherapy, Cancer Discovery, 2021 Mar 3:candisc.0962.2020.
  16. Yalong Wang, Kaixin He, Baifa Sheng B, Xuqiu Lei, ..., Jun Wang , Mingsong Li M, Kaiguang Zhang , Lin Li, Hua Yang, Hua-bing Li, Richard A. Flavell, Shu Zhu. The RNA helicase Dhx15 mediates Wnt-induced antimicrobial protein expression in Paneth cells. PNAS. 2021.
  17. Jingwei Sun, Qiao Lu, Miguel F. Sanmamed, Jun Wang*. Siglec-15 as an emerging target for next-generation cancer immunotherapy. Clinical Cancer Research. February 1 2021 (27) (3) 680-688. (*Corresponding author)
  18. Ting Zhou, Tina Tianjiao Su, Tenny Mudianto, Jun Wang*; Immune asynchrony in COVID-19 pathogenesis and potential immunotherapies. J Exp Med. 5 October 2020; 217 (10): e20200674. (*Corresponding author)
  19. Ting Zhou, William Damsky, Orr-El Weizman, Meaghan K McGeary, K. Patricia Hartmann, Connor E. Rosen, Ruaidhri Jackson, Suzanne Fischer, Jun Wang, Miguel F. Sanmamed, Richard A. Flavell, Marcus W. Bosenberg, Aaron M. Ring, IL-18BP is a secreted immune checkpoint and barrier to effective IL-18 Immunotherapy. Nature, 583, 609–614 (2020).
  20. Yanan Li#, Jun Wang#, Kun Song,..., Zhihai Qin, Jinhua Zhang. S100A4 promotes hepatocellular carcinogenesis by intensifying fibrosis-associated cancer cell stemness. Oncoimmunology. 2020 Jan 1;9(1):1725355. (# Co-first authors)
  21. Su, Tina Tianjiao, Xiaobin Gao, and Jun Wang*. A tumor-localized approach to bypass anti-4-1BB immuno-toxicity. Clinical Cancer Research, clincanres-1799 (2019). (*Corresponding author)

Before NYU

  1. Jun Wang, Miguel F. Sanmamed, Ila Datar, Tina Tianjiao Su, Lan Ji, Jingwei Sun, Ling Chen, Yusheng Chen, Gefeng Zhu, Weiwei Yin, ..., Mario Sznol, Ignacio Melero, Dario A. A. Vignali, Kurt Schalper, Lieping Chen. Fibrinogen-like Protein 1 is a major immune inhibitory ligand for LAG3. Cell 176, 334-347 e312 (2019).
  2. Jun Wang#, Jingwei Sun#, Linda N. Liu, Dallas B. Flies, Xinxin Nie, Maria Toki, Jianping   Zhang, Chang Song, Melissa Zarr, ..., Roy S. Herbst, Agedi N. Boto, Miguel F. Sanmamed, Solomon Langermann, David L. Rimm, Lieping Chen. Siglec-15 as an immune suppressor and a potential target for normalization cancer immunotherapy. Nature Medicine 25, 656-666 (2019) (# Co-first authors)
  3. Yichen Chen#, Jun Wang#, et al. Pik3ip1 is an immune negative regulator that inhibits T cell responses and anti-tumor immunity. Clinical Cancer Research 25(20):6180-6194 (2019). (# Co-first authors)
  4. Jinhua Zhang#, Kun Song#, Jun Wang#, et al., S100A4 blockage alleviates agonistic anti-CD137 antibody induced liver pathology without disruption of anti-tumor immunity. Oncoimmunology 23:7(4) (2018). (# Co-first authors)
  5. Ila Datar, Miguel Sanmamed, Jun Wang, Nikita Mani, Franz Villarroel-Espindola, Patrick Ryan, Kristen McEachern, David Jenkins, David L. Rimm, Lieping Chen, Roy S. Herbst and Kurt A. Schalper. Simultaneous measurement and clinical significance of PD-1, LAG-3 and TIM-3 in non-small cell lung cancer (NSCLC). Clinical Cancer Research, clincanres-4142 (2019).
  6. Di Liu, Xing Wang, Qian Lu, Jun Wang, Jing Liu, Dianyuan Zhao, Pengbo Cao, Yuandong Tao, Zaopeng Yang, Fuchu He, Li Tang. LSECtin on tumor-associated macrophages advances breast cancer stemness via interaction with BTN3A3. Cell Research 29(5):365-378 (2019).
  7. Jun Wang, Ruirong Yuan, Wenru Song, Jingwei Sun, ..., Zihai Li. PD-1, PD-L1(B7-H1) and Tumor-Site Immune Modulation Therapy: The Historical Perspective. Journal of Hematology and Oncology 10(34) (2017).
  8. Cariad Chester, Miguel F. Sanmamed, Jun Wang, Ignacio Melero. Immunotherapy targeting 4-1BB: mechanistic rationale, clinical results, and future strategies. Blood (06), 741041 (2017).
  9. MF Sanmamed, JL Perez-Gracia, KA Schalper, JP Fusco, A Gonzalez, ..., M Morgado, J Wang, A Bacchiocchi, R Halaban, H Kluger, L Chen, M Sznol, I Melero; Changes in serum interleukin-8 (IL-8) levels reflect and predict response to anti-PD-1 treatment in melanoma and non-small cell lung cancer patients. Annals Oncology mdx190 (2017).
  10. Yuwen Zhu, Sheng Yao, Matthew Augustine, Haiying Xu, Jun Wang, et al. Neuron-specific SALM5 limits inflammation in the CNS via its interaction with HVEM. Science Advances 2(4): e1500637(2016).
  11. Lin Chen, Jie Li, Jinhua Zhang, Liangcheng Dai, Xiaoman Liu, Jun Wang, Zhitao Gao, Hongyan Guo, Rui Wang, ..., Shengdian Wang, Zhihai Qin. S100A4 promotes liver fibrosis via activation of hepatic stellate cells, Journal of Hepatology 62:1:156-64 (2015).
  12. Jun Wang and Lieping Chen. Myeloid Cells’ Evasion of Melanoma Immunity, Journal of Investigative Dermatology jid.2014.333 (2014).
  13. Yan Luan, Jianqi Ju, Liqun Luo, Zheng Zhang, Jun Wang, Dan-Ming Zhu, Liang Cheng, Shu-Ye Zhang, Lieping Chen, Fu-Sheng Wang, Shengdian Wang. Potential role of soluble B7-H3 in liver immunopathogenesis during chronic HBV infection, Journal of Viral Hepatitis 1:23-31 (2012).
  14. Liang Cheng, Jun Wang, Xiaozhu Li, Qiao Xing, Peishuang Du, Lishan Du, Shengdian Wang. Interleukine-6 Induces Gr-1+CD11b+ Myeloid Cells to Suppress CD8+ T Cell-Mediated Liver Injury in Mice, PLoS One 6(3): e17631 (2011).
  15. Jun Wang, Wenxia Zhao, Liang Cheng, Mingzhou Guo, Dongling Li, Xiaozhu Li, ..., Lieping Chen and Shengdian Wang. CD137-Mediated Pathogenesis from Chronic Hepatitis to Hepatocellular Carcinoma in HBV Transgenic Mice, J Immunol 185 (12) (2010).

Book Chapters

  1. Jun Wang and Lieping Chen. Anti-B7-H4. In: Encyclopedia of Cancer Therapeutic Targets. Marshall JL, Weiner L, Gelmann E, Kaufman H and Wellstein A, eds., Springer-Verlag, Berlin Heidelberg, ISBN-10: 1441907165, June 2013.
  2. Jun Wang, Yanyi Wang, Shengdian Wang, et al., In: Antiviral Innate Immunity, Hong-bing Shu, ed., Science Press, Beijing, ISBN: 9787030254887,2009

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