The goal of the Jun Wang laboratory at NYU is to dissect the divergent and convergent immunological mechanisms within the disease microenvironment and to maximize immune modulation for cancer and the other immunological diseases, such as autoimmune or infectious diseases. To this end, we are interested in discovering novel targeted immunotherapies beyond anti-PD-1/PD-L1, and optimizing current therapies by protein engineering or rational drug design to balance efficacy versus immune-toxicity.